PlateKi Determination of inhibition constants and IC-50 from plate-reader data
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PlateKi Description

The PlateKi application can be used in leading pharmaceutical research laboratories to determine "tight-binding"or "classical" inhibition constants from raw plate-reader data. Associated IC50 values are also determined for compatibility with most corporate databases. Benefits: - High processing speed (approximately 100 milliseconds per inhibition constant, including progress curve analysis). - Outlier exclusion minimizes labor and removes subjective bias. - Can be used for secondary in-vitro screening of purified enzymes, or in cell-based assays. - Summary output file can be imported into Excel and/or corporate databases. NOTE: Request or activate the PlateKi license here. Main features: Automatic model selection in fitting the reaction progress curves (straight line, quadratic parabola, first or second degree exponential). Automatic initial estimate of the inhibition constant . Optional robust regression with automatic exclusion of outliers . Determination of nonsymmetrical confidence intervals for model parameters according to the profile-t method (Bates & Watts, 1988). Fitting of dose-response curves either to the Morrison equation for tight binding or to the four-parameter logistic equation.

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