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The Open Source Microscopy Project "µMANAGER" at the Vale laboratory at UCSF is Currently funded by the Sandler Foundation. Its main objective is to provide a universal, flexible and low-cost software platform for automated microscopy. In order to provide lasting value and real benefit to a wide community of researchers, we have taken the approach of building a self-contained software product, with quality and ease-of-use standards equal to commercial software. At the same time µManager project leverages other Open Source tools and components to the maximum extent possible. New Features in Micro-Manager 1.3: Faster live mode (using camera sequence mode, in collaboration with 100XImaging) New Micro-Manager plugin mechanism (provided by 100XImaging) Keratocyte Tracker plugin (provided by 100XImaging) New "Acquire" button collects series of still images with metadata Keyboard commands to MOVE stages New autofocussing mechanism (provided by 100XImaging) Improved Script Panel (new interactive BeanShell interpreter) Extensions to the scripting interface Python wrapper for the Micro-Manager core Many minor bugfixes in all parts of the application New Devices: ABSCameras (provided by Michael HimmelReich) Arduino digital IO board Piper (Stanford Photonics cameras, provided by Stanford Photonics) Leica DMI microcopes (provided by 100XImaging) Scion, Leica, and Diagnostic SPOT cameras Coherent Cube, Thorlabs LED controller, Neos AOTF controller Device updates: New Olympus IX81 support Andor added external triggers and updated support for new cameras Nikon TE2000 added filter wheel (100X Imaging) Moved DAZStage, DAShutter and MultiShutter into adapter Utilities Added StateDeviceShutter (in Utilities) that enables using a filter wheel as a shutter

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